Development of menaquinone-7 enriched nutraceutical: inside into medium engineering and process modeling

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چکیده

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Convergent Synthesis of Menaquinone‐7 (MK-7)

A practical synthesis of menaquinone-7 (MK-7, vitamin K2) in the all-trans form was designed. Stereoselective synthesis of MK-7 was achieved through a “1 + 6” convergent strategy by condensation of two building blocks, menadione monoprenyl derivative (fragment “1”) with hexaprenyl bromide (fragment “6”, 82%). Pd-catalyzed desulfonation with LiEt3BH (78%) was followed by oxidation of the hydroqu...

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Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

BACKGROUND Vitamin K₂ contributes to bone and cardiovascular health. Therefore, two vitamin K₂ homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health. However, little is known about the bioavailability of nutritional MK-4. To investigate MK-4 and MK-7 bioavailability, nu...

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ژورنال

عنوان ژورنال: Journal of Food Science and Technology

سال: 2014

ISSN: 0022-1155,0975-8402

DOI: 10.1007/s13197-014-1600-7